I'm going to end it all...

Now I have your attention, you might realise I wasn't talking about topping meself but I refer to you having the power to end a television series or a film stone dead. You can be as innovative as you want and create the perfect ending in one or two sentences and kill it off immediately. The more creative and clever the better.
Go have a go, let's see if you can use that power for evil doings mwaahhhhhhhhhha

I'll have a think about it and add my ideas later.
Good luck.

Eastenders.

Stolen Russian Suitcase Nuke wipes out Albert Square and all the miserable fuckers who live there.

Doctor Who.

Become the controller of BBC1.
Take the show off the air for 18 months.
Bring it back with a reduced season of half the number of episodes and starve it of budget.
Sack the leading actor when the ratings don't improve.
Repeat as necessary.

Oh no, wait, they already did all that in the 1980s.
Sorry, you wanted something innovative.